The office of celebrity divorce lawyer Jonathan Wolfe confirmed the divorce. "This is a personal and private matter" he said in a statement.
The couple have a six-year daughter, Suri, and Cruise, 49, has two children from his marriage to Nicole Kidman.
Cruise married Holmes, 33, his third wife, in an Italian castle in November 2006.
A spokesman for Cruise said: "Kate has filed for divorce and Tom is deeply saddened and is concentrating on his three children. Please allow them their privacy."
It is not yet clear whether divorce papers have been filed in court.
The divorce brings to an end a relationship that began with very public declarations of affection.
Holmes once admitted she had a childhood crush on the Hollywood celebrity, while Cruise famously jumped on a sofa on the Oprah Winfrey Show as he declared his love for Holmes.
"I can't be cool. I can't be laid-back. Something happened and I want to celebrate it," Cruise said in his appearance on the show.
Cruise proposed to Holmes at the Eiffel Tower in Paris and the couple were married by a Church of Scientology minister.
Tom Cruise is among Hollywood's highest-paid actors and has starred in blockbusters such as Top Gun, Jerry Maguire and the Mission Impossible series.
Earlier this week he was reported to be in Iceland shooting an upcoming film called Oblivion. He also starred in the recently released Rock Of Ages.
Katie Holmes rose to fame as a leading actress on US television drama Dawson's Creek. She has also appeared in Batman Begins and Don't Be Afraid Of The Dark.
Source: BBC News
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